IMPROVEMENT OF THE METHOD OF OBTAINING USNIC ACID FROM THE LICHEN CLADONIA RANGIFERINA HOFF

Relevance. Contemporary pharmaceutical industry requires constant search and development of new technologies for the production of pharmacological products. At the same time, the processing of plants, which contain substances with a therapeutic effect, is a promising direction. Their use in terms of economic and therapeutic effectiveness is sometimes very beneficial. It has been proven that lichen plants contain substances that have a therapeutic effect. Organisms of the genus Cladonia, which synthesize usnic acid, among them have a special significance and application. The extraction of usnic acid from lichen biomass is carried out using various organic solvents. At the same time, it is preferable to use techniques with the lowest cost with a high quantitative yield of extractives. In addition, extracts containing bioactive substances should exhibit significant biological activity. The aim is improving the technology of extraction of usnic acid from the vegetable raw materials of Cladonia rangiferina Hoff by determining the optimal components for its extraction. Materials and methods. The material for the study is raw material of Yagel (Deer Moss)/Cladonia rangiferina Hoff. The extractive properties of the most commonly used solvents (purified water, ethyl alcohol 40, 70 and 95%) were studied, among which the most effective was identified. The content of extractive substances was determined by the gravimetric analysis method. The results of the study. According to the results of a series of experiments to study extractive capabilities, of all solvents, the maximum extractive ability of extractive substances from Cladonia rangiferina Hoff was noted for 95% ethyl alcohol (7.38%). Ethyl alcohol 70% was produced with a high extraction capacity, however, it turned out to be less effective. The conclusion was made about these methods can be used to detect biologically active substances obtained from the raw materials of Cladonia rangiferina Hoff. The obtained developments create prerequisites for the development of regulatory documentation on the procedure and position of the relevant standard or a temporary pharmacopoeia article.