POSSIBILITIES OF USING NON-INVASIVE OPHTHALMOLOGICAL METHODS FOR DIAGNOSING PATHOLOGICAL CONDITIONS OF EARLY AGING ON A PRIMATE MODEL

Currently, there is an urgent need for early diagnostics, searching for means of predicting the development of cognitive deficit, and assessing the dynamics of changes during treatment. Given the common origin of the brain and eye, which undergo the same onto- and phylogenetic development, some researchers have suggested that the eye can act as a “window” for easily accessible and non-invasive methods for studying brain pathology [3]. The popularity of fundamental research is growing, and interest in creating disease models in primates is becoming more relevant. The creation of such models will significantly expand the possibilities of obtaining the most reliable information, especially in the field of gerontology and brain pathology (cataract, senile ring, age-related changes in the fundus and other signs of early aging). In this part of the work, approaches to studying the fundus, physiological parameters of the structures and functions of the visual organ in rhesus macaques and hamadryas baboons of different ages are developed; potential ophthalmological biomarkers for diagnosing early aging processes are considered. A combined approach using ophthalmological markers, including non-invasive visualization of the retina and detection of pathological proteins in the intraocular fluid, lens or retina, in combination with biomarkers of oxidative stress (malondialdehyde, lipofuscin, protein carbonyls, 8-OH-deoxyguanosine) will allow us to develop a methodology for diagnosing the development and correction of early aging in humans on a primate model.