DESIGN OF A SOFT MEDICINAL FORM BASED ON PLANT RAW MATERIALS OF DEER MOSS (CLADONIA RANGIFERINA), WHICH HAS AN ANTISEPTIC EFFECT

Relevance. Contemporary realities dictate the need to search for and create new medicines, including extracts obtained from plant raw materials. The use of medicinal plants often turns out to be more favorable in terms of economic and therapeutic effectiveness, sometimes very profitable. This is especially true with regard to drugs against infectious pathogens, since many of them have developed resistance to antibiotics. Lichens are known to contain substances with antibacterial properties. Among the extracted components from lichens, usnic acid is considered one of the most promising. Work is underway to include it in the composition of dosage forms for treatment. The development of drugs for external use that contain usnic acid is considered the most studied and preferred. The aim Design of a soft medicinal form (gel) based on vegetable raw materials of Deer moss (Cladonia rangiferina), which has an antiseptic effect. Materials and methods. The materials for the creation of an antiseptic gel were: usnic acid extract isolated from Deer moss (Cladonia rangiferina); substances that form the basis of gel dosage forms (carbopol, polyethylene glycol). 3 experimental series of gel containing usnic acid have been produced. Their organoleptic and physico-chemical properties have been studied. The results of the study. Based on the results of a series of experiments, the best composition for the preparation and production of a gel containing usnic acid was determined. It includes the following component ratios: extract of usninic acid from alcohol berry 1:10 (20 ml); carbopol (0.8 g); polyethylene glycol-6000 (0.1 g). The conclusion the optimal composition of an antiseptic gel containing usnic acid has been determined. A recipe has been compiled for the manufacture of gel based on vegetable raw materials of Deer moss.

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Publication Details

Journal
Medical & pharmaceutical journal Pulse
Published
2024-10-20
DOI
https://doi.org/10.26787/nydha-2686-6838-2024-26-10-96-103
Primary Topic
Phytochemistry and Biological Activities
Type
article
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article

DESIGN OF A SOFT MEDICINAL FORM BASED ON PLANT RAW MATERIALS OF DEER MOSS (CLADONIA RANGIFERINA), WHICH HAS AN ANTISEPTIC EFFECT

Krylov I.A., Д. В. Шатов, Kubasova E.D., Eroshenko A.Yu. et al.
Medical & pharmaceutical journal Pulse
Phytochemistry and Biological Activities
article

DESIGN OF A SOFT MEDICINAL FORM BASED ON PLANT RAW MATERIALS OF DEER MOSS (CLADONIA RANGIFERINA), WHICH HAS AN ANTISEPTIC EFFECT

Krylov I.A., Д. В. Шатов, Kubasova E.D., Eroshenko A.Yu., А. В. Сафроненко, R. V. Koubassov, Н. В. Сухорукова, A. E. Sukhanov, Sidek L.M, Korobitsyn A.P., T A, Linchenko S.N., Galina S. Groshilina
article en

Abstract

Relevance. Contemporary realities dictate the need to search for and create new medicines, including extracts obtained from plant raw materials. The use of medicinal plants often turns out to be more favorable in terms of economic and therapeutic effectiveness, sometimes very profitable. This is especially true with regard to drugs against infectious pathogens, since many of them have developed resistance to antibiotics. Lichens are known to contain substances with antibacterial properties. Among the extracted components from lichens, usnic acid is considered one of the most promising. Work is underway to include it in the composition of dosage forms for treatment. The development of drugs for external use that contain usnic acid is considered the most studied and preferred. The aim Design of a soft medicinal form (gel) based on vegetable raw materials of Deer moss (Cladonia rangiferina), which has an antiseptic effect. Materials and methods. The materials for the creation of an antiseptic gel were: usnic acid extract isolated from Deer moss (Cladonia rangiferina); substances that form the basis of gel dosage forms (carbopol, polyethylene glycol). 3 experimental series of gel containing usnic acid have been produced. Their organoleptic and physico-chemical properties have been studied. The results of the study. Based on the results of a series of experiments, the best composition for the preparation and production of a gel containing usnic acid was determined. It includes the following component ratios: extract of usninic acid from alcohol berry 1:10 (20 ml); carbopol (0.8 g); polyethylene glycol-6000 (0.1 g). The conclusion the optimal composition of an antiseptic gel containing usnic acid has been determined. A recipe has been compiled for the manufacture of gel based on vegetable raw materials of Deer moss.

Medical & pharmaceutical journal Pulse
Rostov State Medical University (RU), Kuban State Medical University (RU), Northern State Medical University (RU)
Openalex Percentile: Top 90%
Phytochemistry and Biological Activities
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