Anti-RBD IgG dynamics following infection or vaccination
Identifying parameters influencing SARS-CoV-2 antibody dynamics post infection or vaccination is crucial for refining vaccination strategies. In a longitudinal analysis of 1340 samples from 375 healthcare workers, we characterized peak serological response and IgG half-life. Peak antibody titers post 2 vaccine doses were ∼ 20 times higher than natural infection; conversely, infected individuals had extended antibody half-life. Clinical and demographical factors such as BMI, age and smoking shaped peak response without affecting anti-RBD IgG half-life. A third mRNA vaccine dose increased peak antibody titers and prolonged half-life compared to the second dose. These findings underscore the diverse kinetics of SARS-CoV-2 antibody responses, which is influenced by immunization type/number and clinical factors.
Authors
- Laurence Generenaz (ORCID: https://orcid.org/0009-0007-6691-631X)
- Sophie Trouillet‐Assant (ORCID: https://orcid.org/0000-0001-6439-4705)
- Mary‐Anne Trabaud (ORCID: https://orcid.org/0000-0001-8614-1071)
- Jean‐Baptiste Fassier (ORCID: https://orcid.org/0000-0003-3885-4987)
- Antonin Bal (ORCID: https://orcid.org/0000-0002-0261-2495)
- Sylvie Pons (ORCID: https://orcid.org/0000-0002-6286-0546)
- Bouchra Mokdad (ORCID: https://orcid.org/0009-0003-1017-0564)
- Carla Saade (ORCID: https://orcid.org/0000-0001-5964-0588)
- Muriel Rabilloud (ORCID: https://orcid.org/0000-0003-1324-0356)
- Kahina Saker (ORCID: https://orcid.org/0000-0001-8825-5400)
- Amira Harrache
- Amna Abichou-Klich
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Centre National de la Recherche Scientifique (FR)
- Hôpital de la Croix-Rousse (FR)
- Laboratoire Analyse et Modélisation pour la Biologie et l'Environnement (FR)
- Hospices Civils de Lyon (FR)
- Laboratoire de Biométrie et Biologie Evolutive (FR)
- Virologie et Pathologies Humaines (FR)
- Centre International de Recherche en Infectiologie (FR)
- Unité Mixte de Recherche Epidémiologique et de Surveillance Transport Travail Environnement (FR)
Publication Details
- Journal
- Vaccine
- Published
- 2024-10-20
- DOI
- https://doi.org/10.1016/j.vaccine.2024.126464
- Citations
- 3
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- Agence Nationale de Recherches sur le Sida et les Hépatites Virales