The activated caveolin‐3/μ‐opioid receptor complex drives morphine‐induced rescue therapy in failing hearts
Our data suggest that up-regulation of the Cav3/μ receptor complex is critical for morphine protection of the failing heart against I/R injury by regulating the ERK1/2 pathway. The activated Cav3/μ receptor complex is an understudied therapeutic target for opioid treatment of heart failure and ischaemic insult.
Authors
- Shiyun Jin (ORCID: https://orcid.org/0000-0003-2610-3318)
- Shufang He (ORCID: https://orcid.org/0000-0001-9896-5705)
- Juan Wu (ORCID: https://orcid.org/0000-0002-2580-9936)
- Wenyi Peng (ORCID: https://orcid.org/0000-0001-6399-5250)
- Xinxin Pan
- Mengyun Dou
- Sihe Zhang (ORCID: https://orcid.org/0000-0002-8923-1993)
- Chengxiao Guo
- Xinyu Chen (ORCID: https://orcid.org/0000-0001-9422-2584)
- Ye Zhang (ORCID: https://orcid.org/0000-0002-0627-7057)
- Rui Zhu (ORCID: https://orcid.org/0000-0003-4680-5173)
- Chao Wu (ORCID: https://orcid.org/0000-0002-1331-2746)
- Shijin Xu
- Baoli Wang
Institutions
- Anhui Medical University (CN)
- Nankai University (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2024-10-20
- DOI
- https://doi.org/10.1111/bph.17326
- Citations
- 5
- Primary Topic
- Cardiac Ischemia and Reperfusion
- Type
- article
- Field-Weighted Citation Impact
- 2.12
Funders
- National Natural Science Foundation of China