Anti-Oxidant and Anti-Cancerous Properties of Pyrus pashia (Buch. -Ham.Ex D.Don) Against KB-3-1 Cancer Cell Lines In Vitro

Background: Oral cancer is the fastest-growing cancer in men. Many medicinal approaches are tried step-wise for cancers. Homeopathy and Ayurveda are contributing much to cure cancers without side effects. Plants having antioxidant properties are now being utilized with different solvents to extract different chemical compounds to cure cancer. Objective: The current study aimed to examine the anti-cancer and antioxidant properties of acetone extract of Pyrus pashia (PP-AE) fruit against KB-3-1 cancer cell lines. Materials and Methods: The extract's total phenolic content was determined using a folin-ciocalteu reagent. The DPPH, ABTS, and H2O2 assay were used to measure the free radical scavenging activity of the PP-AE. The MTT assay was used to evaluate the cytotoxic efficacy of the PP-AE against KB-3-1 cancer cell lines at various concentrations. Results: Based on the observations, the total phenolic content was present in the PP-AE of fruit and all free radical scavenging assays have shown remarkable IC50 values. Conclusion: According to the current study, acetone extract of Pyrus pashia fruit significantly possesses antioxidant and anti-cancer properties against oral (KB-3-1) cancer cell lines. This effect may be used in the future to analyze particular chemical compounds in extract, capable of minimizing the growth of oral cancer cells.