Multifunctional Carbon Dots Derived from Human Hair for Fast Healing Wounds Together with Oleogels

In the complex process of wound healing, oleogels (OG) are suitable as the primary component of dressing materials, but they cannot meet the diverse requirements at different healing stages. In this study, a new kind of carbon dots (CrCi‐CDs) prepared by carbonizing human hair, exhibits excellent hemostatic, antibacterial, anti‐inflammatory, and pro‐angiogenic properties and thus supports the various stages of wound healing effectively. Such CrCi‐CDs are incorporated into OG to produce a CrCi‐CD/OG composite material with enhanced multifunctional capabilities, significantly outperforming OG alone. Various experiments in vitro and in vivo confirm that the CrCi‐CDs/OG can rapidly achieve hemostasis at the initial stage of wound formation, subsequently inhibit bacterial proliferation and biofilm formation, improve the complex microenvironment surrounding the wound, and promote neovascularization, ultimately accelerating the wound repair.

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Publication Details

Journal
Small Structures
Published
2024-10-20
DOI
https://doi.org/10.1002/sstr.202400435
Citations
12
Primary Topic
Electrospun Nanofibers in Biomedical Applications
Type
article
Field-Weighted Citation Impact
2.08

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article

Multifunctional Carbon Dots Derived from Human Hair for Fast Healing Wounds Together with Oleogels

Zhaonan Sun, Yuanqing Mao, Xiaofeng Shi, Jingwei Zhang et al.
12 citations
Small Structures
Electrospun Nanofibers in Biomedical Applications
2.08
article

Multifunctional Carbon Dots Derived from Human Hair for Fast Healing Wounds Together with Oleogels

Zhaonan Sun, Yuanqing Mao, Xiaofeng Shi, Jingwei Zhang, Xinlin Jia, Wei Xu, Zhao‐Fan Wu, Huan‐Ming Xiong, Qianli Ma, Chaohong Yu, Tian Gao
article en
12 citations

Abstract

In the complex process of wound healing, oleogels (OG) are suitable as the primary component of dressing materials, but they cannot meet the diverse requirements at different healing stages. In this study, a new kind of carbon dots (CrCi‐CDs) prepared by carbonizing human hair, exhibits excellent hemostatic, antibacterial, anti‐inflammatory, and pro‐angiogenic properties and thus supports the various stages of wound healing effectively. Such CrCi‐CDs are incorporated into OG to produce a CrCi‐CD/OG composite material with enhanced multifunctional capabilities, significantly outperforming OG alone. Various experiments in vitro and in vivo confirm that the CrCi‐CDs/OG can rapidly achieve hemostasis at the initial stage of wound formation, subsequently inhibit bacterial proliferation and biofilm formation, improve the complex microenvironment surrounding the wound, and promote neovascularization, ultimately accelerating the wound repair.

Small StructuresVol. 6(3)
Shanghai Jiao Tong University (CN), Fudan University (CN), Shanghai Ninth People's Hospital (CN)
National Key Research and Development Program of China
Openalex Percentile: Top 14%
Electrospun Nanofibers in Biomedical Applications
2.08
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Multifunctional Carbon Dots Derived from Human Hair for Fast Healing Wounds Together with Oleogels — Zhaonan Sun, Yuanqing Mao, et al. · Small Structures (2024) | TGRS Research Map | TGRS