Enhancing Th17 cells drainage through meningeal lymphatic vessels alleviate neuroinflammation after subarachnoid hemorrhage
This study shows that improving the drainage of Th17 cells by meningeal lymphatics via the CCR7-CCL21 pathway can reduce brain damage and improve behavior in the SAH mouse model. This could lead to new treatment options for SAH.
Authors
- Xinyu Yang (ORCID: https://orcid.org/0000-0002-2194-4137)
- Pengyu Pan (ORCID: https://orcid.org/0000-0001-8694-5483)
- Guobiao Liang (ORCID: https://orcid.org/0000-0001-6332-190X)
- Dandan Gao (ORCID: https://orcid.org/0000-0001-8928-1598)
- Kunyuan Zhu
- Wenxu Zhang (ORCID: https://orcid.org/0000-0001-6625-5522)
- Bin Zou
- J. Lai (ORCID: https://orcid.org/0009-0004-1002-9947)
- Shijun Bi
Institutions
- Dalian Medical University (CN)
- Northern Hospital (AU)
- General Hospital of Shenyang Military Region (CN)
- China Medical University (CN)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2024-10-20
- DOI
- https://doi.org/10.1186/s12974-024-03252-y
- Citations
- 17
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 4.56
Funders
- National Natural Science Foundation of China