Unraveling the causal association between lifestyle and metabolic factors with endometrial cancer: evidence from a Mendelian randomization study
Our findings underscore a causal association between genetically predicted lifetime smoking index, alcohol intake frequency, BMI, T2DM, and fasting insulin with EC risk. Furthermore, our study highlights the potential protective effects of a high education level, moderate-intensity physical exercise, and LDL reduction against EC risk. This MR analysis provided valuable insights into underlying EC risk mechanisms and paved new ways for EC prevention strategies.
Authors
- Jing Wan
- H. Henry Lai (ORCID: https://orcid.org/0000-0003-2691-994X)
- Li Wang (ORCID: https://orcid.org/0000-0001-7692-5067)
- Xu Zhang (ORCID: https://orcid.org/0000-0003-1056-2173)
- Shanshan Wu (ORCID: https://orcid.org/0000-0003-3876-8210)
- Chuanqiang Pu (ORCID: https://orcid.org/0000-0003-0333-1131)
- Xiaona Lin
Institutions
- Sun Yat-sen University (CN)
- Jinan University (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
- First Affiliated Hospital of Jinan University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2024-10-20
- DOI
- https://doi.org/10.1007/s12672-024-01439-6
- Citations
- 1
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.29