Bioactive constituents from Clerodendrum trichotomum and their α-glucosidase inhibitory and PPAR-γ agonist activities
Three new neoclerodane diterpenoids (1-3), two new steroids (4-5), one new monoterpene (6), one new derivative of benzaldehyde (7) and one new iridoid glycoside (8), along with 19 known phenolic compounds, were isolated from Clerodendrum trichotomum. Their structures were established by a combination of detailed spectroscopic analyses (1D and 2D NMR) and high resolution electrospray ionization mass spectroscopy (HRESIMS). The isolated compounds were screened on α-glucosidase inhibitory and the peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist activities, and the results showed that three phenylethanoid glycosides, verbascoside (9), leucosceptoside a (10), and isoacteoside (13), and two flavonoids, apigenin (22) and luteolin (26) showed potent inhibitory effects against α-glucosidase, with IC<sub>50</sub> values in the range from 15 to 700 μM. In addition, four flavonoids apigenin 7-O-β-D-glucuronide (19), apigenin (22), luteolin (26), and quercetin (27) exhibited significant PPAR-γ agonistic activities with EC<sub>50</sub> values in the range 2.3-24.9 μM.
Authors
- Zhu‐Zhen Han
- Yingbo Yang (ORCID: https://orcid.org/0000-0002-8894-2734)
- Meng Wang (ORCID: https://orcid.org/0000-0001-7411-4455)
- Zhengtao Wang (ORCID: https://orcid.org/0000-0003-2797-4625)
- Li Yang (ORCID: https://orcid.org/0000-0003-3922-1823)
- Ying Xiao (ORCID: https://orcid.org/0000-0003-2547-917X)
- Hai-Jun Hu
- Qian Zhang (ORCID: https://orcid.org/0000-0001-5975-9781)
- Jia Wang (ORCID: https://orcid.org/0009-0002-9910-1639)
Institutions
- Heilongjiang University of Chinese Medicine (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Fitoterapia
- Published
- 2024-10-20
- DOI
- https://doi.org/10.1016/j.fitote.2024.106266
- Citations
- 3
- Primary Topic
- Phytochemistry and Biological Activities
- Type
- article
- Field-Weighted Citation Impact
- 1.80
Funders
- National Natural Science Foundation of China
- Program of Shanghai Academic Research Leader