Effects of sleeve gastrectomy and Roux-en-Y gastric bypass on pharmacokinetics of lamotrigine and valproate: A cohort study
Postoperative pharmacokinetic changes for lamotrigine and valproate were modest, but for lamotrigine changes may be larger in patients undergoing RYGB than in those undergoing SG. Given the substantial interindividual variation, therapeutic drug monitoring should be used to capture pharmacokinetic changes and guide dose adjustments after bariatric surgery.
Authors
- Hege‐Merete Krabseth (ORCID: https://orcid.org/0009-0001-9342-582X)
- Olav Spigset (ORCID: https://orcid.org/0000-0001-7902-9014)
- Magnus Strømmen (ORCID: https://orcid.org/0000-0002-4686-0263)
- Arne Helland (ORCID: https://orcid.org/0000-0002-9373-1253)
- Georgios Schoretsanitis (ORCID: https://orcid.org/0000-0002-3851-4117)
Institutions
- Norwegian University of Science and Technology (NO)
- St Olav's University Hospital (NO)
- Donald & Barbara Zucker School of Medicine at Hofstra/Northwell (US)
- Zucker Hillside Hospital (US)
Publication Details
- Journal
- Epilepsy Research
- Published
- 2024-10-20
- DOI
- https://doi.org/10.1016/j.eplepsyres.2024.107469
- Citations
- 2
- Primary Topic
- Pharmacological Effects and Toxicity Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.22
Funders
- St. Olavs Hospital Universitetssykehuset i Trondheim