Bibliometric analysis of chimeric antigen receptor T-cell therapy

Objective: Chimeric antigen receptor T-cell (CAR-T) therapy refers to the genetic material with specific antigen recognition domain and T cell activation signal is transferred into T cells through gene modification technology. By engineering T-cells to specifically target and eliminate tumor cells, CAR-T therapy has shown remarkable efficacy in treating certain hematological malignancies. Understanding its advancements helps optimize therapeutic strategies, enhance patient outcomes, and guide future innovations in immunotherapy. Therefore, this study aims to investigate the progress of CAR-T therapy by bibliometrics. Methods: By using the keywords of “CAR-T therapy” and “immune cells”, all relevant literature were comprehensively searched from the Web of Science. Research trends in related field were analyzed by using VOSviewer, Pajek, Microsoft Excel and Endnote software, to explore research hotspots, development trends, and future directions for CAR-T therapy. Results: The United States emerges as the most productive country in related field, and the institutions with the highest number of publications is the University of Pennsylvania. As for journals, Frontiers in Immunology appears to be one of the most productive journals. Notably, Gottschalk Stephen publishes the largest number of articles. Keyword cluster analysis shows that the current research trend is more focused on immune cell, so as to explore the mechanisms and modalities of CAR-T therapy. Conclusion: This study provides a comprehensive summary and analysis of global research trends in CAR-T therapy. In the past 5 years, the number of high-quality papers in this field has increased significantly. CAR-T therapy has emerged as a beacon of hope for tumor treatment, representing a significant advancement in healthcare for a wide range of patients, including those with major diseases and suboptimal health conditions.