Prussian Blue Nanostructure Conjugated Berberine Improves Inflammatory Response of Rheumatoid Arthritis by Suppressing Necroptosis
Rheumatoid arthritis has serious consequences for human health. Drugs can relieve the symptoms of some patients, but they exert significant toxic side effects. We loaded berberine into the Prussian blue nanostructure, synthesizing BRB-PB composites. It improves photothermal properties and exhibits potent anti-inflammatory and antioxidant effects. BRB-PB composites inhibited RIPK1/RIPK3/MLKL signaling pathway activation in RA synovial tissue, suggesting a unique molecular mechanism that reduces the occurrence of necroptosis and improves RA symptoms. Rapid metabolism and excellent biocompatibility of BRB-PB composites enhanced their safety and efficacy.
Authors
- Sen Lin (ORCID: https://orcid.org/0000-0002-9384-8128)
- Xinran Hu (ORCID: https://orcid.org/0000-0002-4222-5537)
- Baofeng Zhao (ORCID: https://orcid.org/0000-0003-3540-8893)
- Xifan Mei (ORCID: https://orcid.org/0000-0003-3698-0525)
- Yuan Wang (ORCID: https://orcid.org/0000-0001-9178-0919)
- Yixuan Wang (ORCID: https://orcid.org/0000-0002-1923-0338)
- Fang Xu (ORCID: https://orcid.org/0000-0002-7651-5700)
Institutions
- Dalian Medical University (CN)
- Jinzhou Central Hospital (CN)
- Taizhou Second People's Hospital (CN)
- Liaoning Vocational College of Medical (CN)
- Fuzhou Second Hospital (CN)
- First Affiliated Hospital of Bengbu Medical College (CN)
- Affiliated Hospital of Jining Medical University (CN)
- Jinzhou Medical University (CN)
Publication Details
- Journal
- ACS Applied Nano Materials
- Published
- 2024-10-20
- DOI
- https://doi.org/10.1021/acsanm.4c04466
- Citations
- 3
- Primary Topic
- Berberine and alkaloids research
- Type
- article
- Field-Weighted Citation Impact
- 1.34
Funders
- National Natural Science Foundation of China