Lack of AMP-activated protein kinase-α1 reduces nitric oxide synthesis in thoracic aorta perivascular adipose tissue
Murine thoracic aorta PVAT exhibits higher NO synthesis and UCP1 levels than abdominal aortic PVAT. Downregulation of AMPK suppresses NO synthesis which may contribute to the reduced anticontractile activity and reduced brown adipose tissue phenotype of KO thoracic PVAT. The mechanism underlying the effect of AMPK downregulation likely results from increased caveolin-1:eNOS association associated with caveolin-1 Tyr14 phosphorylation.
Authors
- Yazeed Alshuweishi (ORCID: https://orcid.org/0000-0002-9476-8197)
- Ian P. Salt (ORCID: https://orcid.org/0000-0003-0055-3724)
- Simon Kennedy (ORCID: https://orcid.org/0000-0003-0887-5840)
- Ali Al-Ferjani
- Abdullah Naji
- Abdmajid Hwej
Institutions
- University of Tripoli (LY)
- King Saud Medical City (SA)
- King Saud University (SA)
- University Elmergib (LY)
- Najran University (SA)
- University of Glasgow (GB)
Publication Details
- Journal
- Vascular Pharmacology
- Published
- 2024-10-20
- DOI
- https://doi.org/10.1016/j.vph.2024.107437
- Citations
- 5
- Primary Topic
- Cardiovascular Disease and Adiposity
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- Ministry of Higher Education and Scientific Research
- Diabetes UK
- University of Glasgow
- King Saud University