Pharmacokinetics/pharmacodynamics of glucocorticoids: modeling the glucocorticoid receptor dynamics and dose/response of commonly prescribed glucocorticoids
The model is used to relate normal human 24-hour endogenous plasma cortisol levels to transcriptional activity and is applied to the commonly prescribed glucocorticoids (dexamethasone, methylprednisolone, prednisone) in an attempt to provide a pharmacological rationale for the very large therapeutic dosage range that has been traditionally used.
Authors
- David G. Levitt (ORCID: https://orcid.org/0000-0002-3757-4716)
Institutions
- University of Minnesota (US)
Publication Details
- Journal
- ADMET & DMPK
- Published
- 2024-10-19
- DOI
- https://doi.org/10.5599/admet.2414
- Citations
- 2
- Primary Topic
- Adrenal Hormones and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.72