Anti irradiation nanoparticles shelter immune organ from radio-damage via preventing the IKK/IκB/NF-κB activation
NPs-TPP-NIT prevented activation of IKK/IκB/NF-κB signaling, reduced secretion of pro-inflammatory factors, and promoted production of anti-inflammatory factors in the spleen, which exhibited radiation-induced damage repair capability without diminishing the therapeutic effect of radiation therapy. It suggests that NPs-TPP-NIT serve as a potential radioprotective drug to shelter immune organs from radiation-induced damage.
Authors
- Hao Huang (ORCID: https://orcid.org/0000-0002-5570-6145)
- Xiaojun Deng
- Qingyue Da (ORCID: https://orcid.org/0000-0003-2257-4884)
- Linlin Jing (ORCID: https://orcid.org/0000-0002-9234-8850)
- Shigao Huang (ORCID: https://orcid.org/0000-0001-7365-4441)
- Haibo Wang (ORCID: https://orcid.org/0000-0002-0238-3506)
- Miaomiao Li (ORCID: https://orcid.org/0000-0003-4508-196X)
- Min Xu (ORCID: https://orcid.org/0009-0003-5839-0259)
- Lina Zhao (ORCID: https://orcid.org/0000-0002-0011-6471)
Institutions
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Central Hospital of Wuhan (CN)
- Xijing Hospital (CN)
- Shaanxi University of Chinese Medicine (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Molecular Cancer
- Published
- 2024-10-19
- DOI
- https://doi.org/10.1186/s12943-024-02142-4
- Citations
- 23
- Primary Topic
- Genomics, phytochemicals, and oxidative stress
- Type
- article
- Field-Weighted Citation Impact
- 5.38
Funders
- National Natural Science Foundation of China