EFNA5 suppresses cell proliferation and tumor metastasis in hepatoma via epithelial-to-mesenchymal transition
The expression of EFNA5 was low in hepatoma cells. An increase in EFNA5 levels hinders the proliferation, invasion, and migration of hepatoma cells. These effects may occur through inhibition of hepatoma epithelial-mesenchymal transition by EFNA5. Moreover, the study on the mechanisms of proliferation, invasion and metastasis of hepatoma provides a novel theoretical basis, and may influence the clinical practice of tumor treatment in the future.
Authors
- Junhao Lin (ORCID: https://orcid.org/0000-0003-2063-939X)
- Shulu Hu
- Xiuqiong Wu
- Yangfeng Zhang
- Fengsheng Chen (ORCID: https://orcid.org/0000-0001-5806-4638)
- Xiangyu Zhong (ORCID: https://orcid.org/0009-0006-9581-741X)
- Zhiqin Zhu
Institutions
- Central South University (CN)
- Hunan Cancer Hospital (CN)
- TCM-Intigrated Cancer Center of Southern Medical University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2024-10-19
- DOI
- https://doi.org/10.1007/s12672-024-01454-7
- Citations
- 2
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.57
Funders
- Beijing Xisike Clinical Oncology Research Foundation
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province