Deposit of pathogenic microbial strains as a basis for biosafety

The spread of animal infections is a major biological threat given the large number of animals imported into the Russian Federation in recent years. The deposit of already studied strains, on the basis of which specific prophylactics are produced, is necessary to prevent biological threats and protect the population and the environment from the impact of dangerous biological factors. Formation, preservation and development of the national collection of pathogenic microorganisms is the main task of the state policy in the field of chemical and biological security in the part concerning resource provision of the national system of chemical and biological security. Studying the properties of microorganism strains, especially those included in the composition of animal medicines, is the key to the epizootic well-being of the region where these vaccines are used. When analysing the monitoring of the epizootic situation on the territory of the Russian Federation, it is possible to assume the effectiveness of the use of a medicinal product through phylogenetic analysis of the genotypes of vaccine strains and isolates isolated in the focus of infection. In this way, it is possible to identify the source of the disease, understand the origin of the pathogen at a certain time interval, and assess the risk of using a particular prophylactic agent. Detailed analysis of isolates in individual regions creates prospects for retrospective analysis and identification of epizootically significant microorganisms in order to assess the variability of their cultural and morphological properties, pathogenicity, as well as to study their resistance to environmental factors and disinfectants. Special attention should be paid to the possibility of validation of diagnostic test systems, which is impossible without the presence of a characterised strain of microorganism.