Isolation and characterization of Yersinia phage fMtkYen3-01
Yersinia enterocolitica causes yersiniosis, the third most common gastrointestinal infection in humans throughout Europe. The emergence of multidrug resistance and the lack of effective new antibiotics have drawn attention to phage therapy as a treatment option. Here, we report the complete genome sequence of phage fMtkYen3-01, which infects Y. enterocolitica serotype O:3 strains. This phage has a genome 40,415 bp in length with 45.1% GC content and 49 predicted genes. fMtkYen3-01 infected 9.5% of the 42 Y. enterocolitica strains tested and showed stability at 25-40 °C, as well as pH 5.0-10.0. These results suggest the therapeutic potential of this phage.
Authors
- Nino Gachechiladze (ORCID: https://orcid.org/0009-0007-3327-6563)
- Daniel de Oliveira Patricio (ORCID: https://orcid.org/0000-0001-8318-3778)
- Henni Tuomala (ORCID: https://orcid.org/0000-0001-7404-7723)
- Mikael Skurnik (ORCID: https://orcid.org/0000-0001-8791-9260)
- Matti Ylänne (ORCID: https://orcid.org/0000-0003-0832-6913)
- Sheetal Patpatia (ORCID: https://orcid.org/0000-0002-7206-5394)
- Lotta‐Riina Sundberg (ORCID: https://orcid.org/0000-0003-3510-4398)
- Sophia Goladze (ORCID: https://orcid.org/0000-0002-1316-6996)
Institutions
- Tbilisi State University (GE)
- University of Helsinki (FI)
- University of Jyväskylä (FI)
Publication Details
- Journal
- Archives of Virology
- Published
- 2024-10-19
- DOI
- https://doi.org/10.1007/s00705-024-06149-6
- Citations
- 4
- Primary Topic
- Bacteriophages and microbial interactions
- Type
- article
- Field-Weighted Citation Impact
- 1.84
Funders
- National Science Foundation
- Academy of Finland
- Shota Rustaveli National Science Foundation
- Jyväskylän Yliopisto
- Opetushallitus