EXPRESSION OF CD34 IN AMELOBLASTOMA AND ODONTOGENIC KERATOCYST

Objectives: To evaluate the expression of CD34 in Ameloblastoma and Odontogenic keratocyst (OKC) in various age groups and to determine the difference in the biological behavior of the lesions according to CD 34 expression.Materials and Methods: This was a comparative cross sectional study of total 80 cases, 40 each of ameloblastoma and OKC which were retrieved from histopathology lab of Peshawar Medical College, Peshawar (PMC) and Pakistan Institute of Medical Sciences, Islamabad (PIMS). The study was conducted at the laboratory of Peshawar Medical College & Peshawar dental college. Mean vascular density was determined. A descriptive analysis was done using SPSS version 21.Results: Mean microvessel density was significantly higher in ameloblastoma as compared to odontogenic keratocyst. Relationship between CD34 expression in ameloblastoma and odontogenic keratocyst was statistically significant (p-value 0.01).Conclusion: This study concludes that CD34 expression is higher in ameloblastoma than odontogenic keratocyst. This is suggestive of more aggressive behavior of ameloblastoma as compared to odontogenic keratocyst and treatment may be modified according to CD34 evaluation. This study also concludes that in case of Ameloblastoma CD34 expression is dependent on different age groups.