Severe cytopenia after chimeric antigen receptor‐T cell driven by large granular lymphocytes and responsive to steroids
Immune effector cell-associated hematotoxicity (ICAHT) is a common toxicity associated with an important morbidity after chimeric antigen receptor (CAR)-T-cell therapy. Multiple factors seem to be involved in the development of severe ICAHT, making its management difficult. Here, we report three cases of severe ICAHT after axicabtagene-ciloleucel (axi-cel) for diffuse large B-cell lymphoma showing an expansion of large granular lymphocyte in the bone marrow with a CD3/CD57-positive non-CAR-T immunophenotype. We show that it is possible to treat them with low-dose steroids, obtaining a striking resolution of cytopenias with no deleterious impact on the underlying malignancy.
Authors
- Éolia Brissot (ORCID: https://orcid.org/0000-0003-4471-418X)
- Antoine Capes (ORCID: https://orcid.org/0000-0002-5086-9519)
- Ludovic Suner (ORCID: https://orcid.org/0000-0002-5107-4961)
- Clémentine Sarkozy (ORCID: https://orcid.org/0000-0002-1942-9304)
- Anne Banet
- Florent Malard (ORCID: https://orcid.org/0000-0002-3474-0002)
- Alexandra Morin
- Nicolas Stocker (ORCID: https://orcid.org/0000-0001-7316-5832)
- Laure Ricard (ORCID: https://orcid.org/0000-0003-4416-3285)
- Zora Marjanovic (ORCID: https://orcid.org/0000-0002-5391-5875)
- Mohamad Mohty (ORCID: https://orcid.org/0000-0001-8536-7781)
- Elise Corre
Institutions
- Inserm (FR)
- Sorbonne Université (FR)
- Hôpital Saint-Antoine (FR)
- Centre de Recherche Saint-Antoine (FR)
- Institut Curie (FR)
Publication Details
- Journal
- British Journal of Haematology
- Published
- 2024-10-19
- DOI
- https://doi.org/10.1111/bjh.19822
- Citations
- 4
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 1.13