Glymphatic system dysfunction and risk of clinical milestones in patients with Parkinson disease
Glymphatic dysfunction, as measured by the DTI-ALPS index, was associated with increased risk of clinical milestones in patients with PD. This finding implies that therapy targeting the glymphatic system may serve as a viable strategy for slowing down the progression of PD.
Authors
- Xiaojie Duanmu
- Xiaojun Guan (ORCID: https://orcid.org/0000-0003-2313-4477)
- Peiyu Huang (ORCID: https://orcid.org/0000-0003-4226-9369)
- Sijia Tan
- Jianmei Qin
- Minming Zhang (ORCID: https://orcid.org/0000-0003-0145-7558)
- Tao Guo (ORCID: https://orcid.org/0000-0002-7340-3762)
- Cheng Zhou (ORCID: https://orcid.org/0000-0003-0770-2649)
- Xiaojun Xu (ORCID: https://orcid.org/0000-0002-0127-2812)
- Jingjing Wu (ORCID: https://orcid.org/0000-0002-7164-0764)
- Weijin Yuan
- Jiaqi Wen (ORCID: https://orcid.org/0000-0001-9723-4695)
- Qianshi Zheng
- Jingwen Chen (ORCID: https://orcid.org/0009-0001-8717-3929)
- Xianchen Jiang
- Haoting Wu
- Chenqing Wu (ORCID: https://orcid.org/0009-0003-3258-2869)
Institutions
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- European Journal of Neurology
- Published
- 2024-10-19
- DOI
- https://doi.org/10.1111/ene.16521
- Citations
- 32
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 8.58
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- National Key Research and Development Program of China
- Natural Science Foundation of Zhejiang Province