Investigating SNHG3 as a potential therapeutic approach for HCC stem cells
This study emphasizes the upregulation of lncRNA SNHG3 and its role in HCC stem cell self-renewal. SNHG3 may regulate the m6A modification of ITGA6 mRNA through its interaction with METTL3, impacting the function of liver cancer stem cells. These findings support the potential of targeting SNHG3 as a therapeutic approach for HCC.
Authors
- Dingmao Wang (ORCID: https://orcid.org/0009-0000-9317-6520)
- Yijun Yang (ORCID: https://orcid.org/0000-0002-9855-9616)
- Xiao Yu (ORCID: https://orcid.org/0009-0007-9796-9510)
Institutions
- Central South University (CN)
- Haikou City People's Hospital (CN)
- Third Xiangya Hospital (CN)
Publication Details
- Journal
- Gene
- Published
- 2024-10-19
- DOI
- https://doi.org/10.1016/j.gene.2024.149022
- Citations
- 1
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- Key Research and Development Project of Hainan Province