Tetrahedral Framework Nucleic Acid-Loaded Retinoic Acid Promotes Osteosarcoma Stem Cell Clearance
Metastatic osteosarcoma is a commonly seen malignant tumor in adolescents, with a five year survival rate of approximately 20% and a lack of treatment options. Osteosarcoma cancer stem cells are considered to be important drivers of the metastasis of osteosarcoma, and therefore their clearance is considered a promising strategy for treating metastatic osteosarcoma. In the relevant literature, retinoic acid (ATRA) is considered effective for eliminating osteosarcoma stem cells, but it has some inherent disadvantages, including poor solubility, difficulty in entering cells, and structural instability. Tetrahedral framework nucleic acids (tFNAs) are a type of nanoparticles that can carry small-molecule drugs into cells to exert therapeutic effects. Therefore, we designed and synthesized a nanoparticle named T-ATRA by using tFNAs to load ATRA and studied its effect in a nude mouse model. T-ATRA is more effective than ATRA in the clearance of osteosarcoma stem cells and in inhibiting osteosarcoma cell metastasis via the Wnt signaling pathway, thus prolonging the survival time of nude mice with osteosarcoma.
Authors
- Yunfeng Lin (ORCID: https://orcid.org/0000-0003-1224-6561)
- Jiangshan Xu
- Zhangheng Huang (ORCID: https://orcid.org/0000-0002-6885-098X)
- Qingquan Kong (ORCID: https://orcid.org/0000-0002-4732-4948)
- Mengqing Li (ORCID: https://orcid.org/0000-0002-0674-5623)
- Zhen Zhao (ORCID: https://orcid.org/0009-0002-1541-8517)
- Pin Feng
- Junlin Liu (ORCID: https://orcid.org/0000-0002-8516-122X)
- Weifei Zhang (ORCID: https://orcid.org/0000-0003-3292-9394)
- Bin Zhang (ORCID: https://orcid.org/0000-0002-3422-6038)
Institutions
- Sichuan University (CN)
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- West China Hospital of Sichuan University (CN)
- Peking University Shenzhen Hospital (CN)
- Stomatology Hospital (CN)
- The Spine Institute (US)
- Tibet Autonomous Region People's Hospital (CN)
- State Key Laboratory of Oral Diseases
Publication Details
- Journal
- ACS Applied Materials & Interfaces
- Published
- 2024-10-19
- DOI
- https://doi.org/10.1021/acsami.4c14440
- Citations
- 5
- Primary Topic
- Advanced biosensing and bioanalysis techniques
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- National Natural Science Foundation of China
- Science, Technology and Innovation Commission of Shenzhen Municipality
- West China Hospital, Sichuan University
- Science and Technology Plan Projects of Tibet Autonomous Region