Inhibition of proteasome activity facilitates definitive endodermal specification of pluripotent stem cells by influencing YAP signalling
Our study unravels the specific involvement of UPS in endoderm cell generation from pluripotent stem cells and paves the way for obtaining potential definitive endodermal cells for plausible cellular therapy in the future.
Authors
- Anujith Kumar
- Smitha Bhaskar
- Akshaya Ashok
- Jyothi Prasanna (ORCID: https://orcid.org/0000-0002-6871-7775)
- Ashwini Ashwathnarayan
- Spandana Shekar
- Guruprasad Kalathur
Institutions
- Manipal Academy of Higher Education (IN)
- Kasturba Medical College, Manipal (IN)
Publication Details
- Journal
- Life Sciences
- Published
- 2024-10-20
- DOI
- https://doi.org/10.1016/j.lfs.2024.123160
- Citations
- 1
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 0.33
Funders
- Department of Science and Technology, Ministry of Science and Technology, India
- Science and Engineering Research Board