Interruption of glucagon signaling augments islet non-alpha cell proliferation in SLC7A2- and mTOR-dependent manners
Our findings demonstrate that interruption of glucagon signaling augments islet non-alpha cell proliferation in zebrafish, rodents, and transplanted human islets in a manner requiring SLC7A2 and mTORC1 activation. An increase in delta cell mass may be leveraged for future beta cell regeneration therapies relying upon delta cell reprogramming.
Authors
- Anna Marie R Schornack (ORCID: https://orcid.org/0000-0001-8991-3882)
- E. Danielle Dean (ORCID: https://orcid.org/0000-0002-7157-5683)
- Dale L. Greiner (ORCID: https://orcid.org/0000-0002-5923-339X)
- Alvin C. Powers (ORCID: https://orcid.org/0000-0003-1941-5786)
- Brittney A. Covington (ORCID: https://orcid.org/0000-0002-1254-3649)
- Chunhua Dai (ORCID: https://orcid.org/0000-0002-6302-7126)
- Greg Poffenberger (ORCID: https://orcid.org/0000-0002-7363-4683)
- Katie C. Coate (ORCID: https://orcid.org/0000-0002-6604-3906)
- Favour O. Oladipupo (ORCID: https://orcid.org/0000-0001-6059-5614)
- Erick Spears (ORCID: https://orcid.org/0000-0003-3345-1724)
- Hai Yan (ORCID: https://orcid.org/0000-0003-0916-8865)
- Jade Stanley (ORCID: https://orcid.org/0000-0002-2741-8437)
- Katelyn Sellick
- Ajay Singh (ORCID: https://orcid.org/0000-0003-2933-4058)
- Yulong Gong (ORCID: https://orcid.org/0000-0003-2241-8718)
- Wenbiao Chen (ORCID: https://orcid.org/0000-0002-0750-8275)
- Amber Bradley (ORCID: https://orcid.org/0000-0002-4912-371X)
- Alexandria Bustabad
- L. D. Shultz
- Tyler Rodgers
- Nandita Dey
- Scott Wisniewski (ORCID: https://orcid.org/0000-0003-3228-6528)
Institutions
- University of Massachusetts Chan Medical School (US)
- Vanderbilt University (US)
- VA Tennessee Valley Healthcare System (US)
- Jackson Laboratory (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2024-10-19
- DOI
- https://doi.org/10.1016/j.molmet.2024.102050
- Citations
- 3
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 1.72
Funders
- U.S. Department of Veterans Affairs
- Vanderbilt University
- Vanderbilt University Medical Center
- Human Islet Research Network
- National Institutes of Health
- Vanderbilt Diabetes Research and Training Center, Vanderbilt University Medical Center