Targeting LDL aggregation decreases atherosclerotic lipid burden in a humanized mouse model of familial hypercholesterolemia: Crucial role of ApoB100 conformational stabilization
DP3 peptide administration inhibits atherosclerosis by preserving the α-helix secondary structures of ApoB100 in a humanized ApoB100 murine model that mimicks the hallmark of human hypercholesterolemia.
Authors
- Antonietta Pepe (ORCID: https://orcid.org/0000-0002-1285-2273)
- Maria Teresa La Chica Lhoëst (ORCID: https://orcid.org/0000-0002-9070-5973)
- Elisa Rubio-García (ORCID: https://orcid.org/0000-0002-2556-8837)
- María Virtudes Céspedes
- Mireia Tondo (ORCID: https://orcid.org/0000-0002-0301-9984)
- Joan Carles Escolà‐Gil (ORCID: https://orcid.org/0000-0001-9021-2485)
- Ana Cenarro (ORCID: https://orcid.org/0000-0002-9973-8982)
- A. Martínez (ORCID: https://orcid.org/0000-0002-7863-8325)
- Aleyda Benitez‐Amaro (ORCID: https://orcid.org/0000-0002-1106-3125)
- Pablo Caruana
- Fernando Civeira (ORCID: https://orcid.org/0000-0001-7043-0952)
- Vicenta Llorente‐Cortés (ORCID: https://orcid.org/0000-0002-0067-7201)
- Roger Prades (ORCID: https://orcid.org/0000-0001-7973-5314)
- Carla Borràs (ORCID: https://orcid.org/0000-0002-0998-7855)
- B Bochicchio
Institutions
- University of Basilicata (IT)
- Barcelona Biomedical Research Park (ES)
Publication Details
- Journal
- Atherosclerosis
- Published
- 2024-10-19
- DOI
- https://doi.org/10.1016/j.atherosclerosis.2024.118630
- Citations
- 4
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 2.29
Funders
- Fundación BBVA
- Centro de Investigación Biomédica en Red Enfermedades Cardiovasculares
- Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
- Instituto de Salud Carlos III
- Departament de Salut, Generalitat de Catalunya