Evaluation of anti-viral photodynamic therapy effects of different concentrations of 5-ALA using light irradiation on HSV-1
5-ALA-mediated PDT demonstrates selective antiviral efficacy against HSV-1, particularly at higher concentrations coupled with light irradiation. These findings underscore the potential of 5-ALA-based PDT as a promising approach for HSV-1 treatment, especially in cases of drug-resistant strains and immunocompromised individuals. Optimization of dosage and treatment protocols is essential for maximizing effectiveness in clinical applications, highlighting the need for further research in this area.
Authors
- Hamed Bagheri
- Sepehr Fekrazad (ORCID: https://orcid.org/0000-0001-7302-6824)
- Mohammad Amin Salehi
- Farhad Farzaneh (ORCID: https://orcid.org/0000-0002-9890-7502)
- Masoud Parsania (ORCID: https://orcid.org/0000-0002-4739-7442)
- Negar Parsania
- Mitra Sadeghpour Natanzi
- Reza Fekrazad
Institutions
- Iran University of Medical Sciences (IR)
- Islamic Azad University North Tehran Branch (IR)
- Aja University of Medical Sciences (IR)
- Islamic Azad University Medical Branch of Tehran (IR)
- Islamic Azad University Sanandaj Branch (IR)
- Universal Scientific Education and Research Network (IR)
- Tehran University of Medical Sciences (IR)
Publication Details
- Journal
- Photodiagnosis and Photodynamic Therapy
- Published
- 2024-10-19
- DOI
- https://doi.org/10.1016/j.pdpdt.2024.104365
- Citations
- 1
- Primary Topic
- Photodynamic Therapy Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.42