Myeloid gasdermin D drives early-stage T cell immunity and peripheral inflammation in a mouse model of Alzheimer’s disease
Our study systematically identified a role for GSDMD in the AD-related peripheral inflammation and early-stage T cell immunity. These findings also suggest the therapeutic potential of targeting GSDMD for the early intervention in AD.
Authors
- Z. Ye
- Yuqing Wu (ORCID: https://orcid.org/0000-0002-5568-2390)
- Jie Ming (ORCID: https://orcid.org/0000-0003-4761-9954)
- Lieying Fan (ORCID: https://orcid.org/0000-0002-0497-6313)
- Wenting Xie (ORCID: https://orcid.org/0000-0003-4387-7577)
- Yongbing Yang
- Xianglong Tang (ORCID: https://orcid.org/0000-0002-1119-2138)
- Sheng Li (ORCID: https://orcid.org/0000-0002-2436-0962)
- Lu Liu (ORCID: https://orcid.org/0000-0001-5101-5067)
- Ming Zong (ORCID: https://orcid.org/0000-0003-4948-0036)
- Wenjuan Rui (ORCID: https://orcid.org/0000-0002-0185-2091)
- De-Long Qin
Institutions
- Jiangnan University (CN)
- Anhui University of Traditional Chinese Medicine (CN)
- Nanjing Brain Hospital (CN)
- Shanghai East Hospital (CN)
- Jiangsu Province Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2024-10-19
- DOI
- https://doi.org/10.1186/s12974-024-03255-9
- Citations
- 5
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Natural Science Foundation of Anhui Province
- Fundamental Research Funds for the Central Universities