Multi-modal characterisation of early-stage, subclinical cardiac deterioration in patients with type 2 diabetes
T2DM prior to cardiovascular disease was linked with a higher heart rate, QTc prolongation, T wave amplitude reduction, as well as lower stroke volume and increased left ventricular wall thickness. Increased QRS duration and left ventricular wall thickness and mass were most strongly associated with future cardiovascular disease. Although subclinical, these changes may indicate the presence of autonomic dysfunction and diabetic cardiomyopathy.
Authors
- Vicente Grau (ORCID: https://orcid.org/0000-0001-8139-3480)
- Ambre Bertrand (ORCID: https://orcid.org/0000-0001-5116-6463)
- Julià Camps (ORCID: https://orcid.org/0000-0002-6491-2565)
- Andrew Lewis (ORCID: https://orcid.org/0000-0002-3714-6711)
- Blanca Rodríguez (ORCID: https://orcid.org/0000-0002-3435-7388)
Institutions
- University of Oxford (GB)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2024-10-19
- DOI
- https://doi.org/10.1186/s12933-024-02465-y
- Citations
- 8
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- Wellcome Trust
- National Institute for Health and Care Research
- British Heart Foundation
- Novo Nordisk
- Engineering and Physical Sciences Research Council
- NIHR Oxford Biomedical Research Centre