Plasma neurofilament light chain as prognostic marker of cognitive decline in neurodegenerative diseases, a clinical setting study
In our clinical cohort, plasma NfL was associated with faster cognitive decline in neurodegenerative dementia, which corroborates data obtained in research cohorts. Yet, plasma NfL was not predictive of accelerated cognitive decline in individuals without neurodegeneration, suggesting its use as a neurodegeneration-specific predictive biomarker.
Authors
- Marta Sanchez-Ortiz
- Claire Hourrègue
- Kaj Blennow (ORCID: https://orcid.org/0000-0002-1890-4193)
- Emmanuel Cognat (ORCID: https://orcid.org/0000-0002-3521-5832)
- Élodie Bouaziz-Amar (ORCID: https://orcid.org/0000-0003-0880-5826)
- A. Raynaud-Simon (ORCID: https://orcid.org/0000-0002-8478-4863)
- Matthieu Lilamand (ORCID: https://orcid.org/0000-0002-4622-2413)
- Julien Dumurgier (ORCID: https://orcid.org/0000-0003-2070-9706)
- Agathe Vrillon (ORCID: https://orcid.org/0000-0002-0761-7885)
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0003-3930-4354)
- Karl Götze
- Sandrine Indart
- Claire Paquet (ORCID: https://orcid.org/0000-0002-2273-7316)
- Matthieu Martinet
- Hela Slimi
Institutions
- University of Science and Technology of China (CN)
- University of Wisconsin–Madison (US)
- Inserm (FR)
- Délégation Paris 7 (FR)
- Université Paris Cité (FR)
- Sahlgrenska University Hospital (SE)
- German Center for Neurodegenerative Diseases (DE)
- Sorbonne Université (FR)
- Sorbonne Paris Cité (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Institute for Neurodegenerative Disorders (US)
- Institut de Myologie (FR)
- Hôpital Lariboisière (FR)
- Pitié-Salpêtrière Hospital (FR)
- UK Dementia Research Institute (GB)
- Institut du Cerveau (FR)
- University College London (GB)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2024-10-19
- DOI
- https://doi.org/10.1186/s13195-024-01593-7
- Citations
- 20
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 7.71