Triiodothyronine (T3), but not resting metabolic rate correlates positively with per- and polyfluoroalkyl substances (PFAS) in Arctic terns

In Arctic seabirds, positive correlations between per- and polyfluoroalkyl substances (PFAS) and thyroid hormones (THs) and resting metabolic rate (RMR) have been documented. Herein we investigated levels and patterns of PFAS in Arctic terns (Sterna paradisaea) nesting in Kongsfjorden, Svalbard (Norway), and if circulating concentrations of PFAS correlated with their circulating concentrations of TH, and the RMR of the birds. The hypothesis was that there will be positive correlations between PFAS, TH, and RMR, indicating that PFAS-induced increases in plasma THs could be responsible for the increased RMR. The dominating PFAS in the terns were perfluorooctane sulfonate (PFOS), perfluoroundecanoate (PFUnDA) and perfluorotridecanoate (PFTrDA). The PFAS pattern was similar to what has been found in other seabirds in Kongsfjorden. There were positive correlations between several PFAS and total triiodothyronine (TT₃) concentrations in the terns. When sex was accounted for there were significant correlations in female terns, but not in males. There were no correlations between PFAS and RMR or between TT₃ and RMR. This indicates that there is no link between a PFAS-induced increase in plasma TT₃ concentrations and a resultant increased RMR. The positive associations between blood PFAS concentrations and plasma TT₃ concentrations may be a passive association, as both PFAS and T₃ bind to thyroid hormone binding proteins (THBP). We recommend that interrelationships between circulating concentrations of PFAS, THs and THBP are investigated further to identify the role of PFAS as TH disrupting chemicals and chemicals that may affect the RMR in birds.