Preoperative prediction of diffuse glioma type and grade in adults: a gadolinium-free MRI-based decision tree
Question Given health and environmental concerns, is there a gadolinium-free imaging protocol to preoperatively evaluate gliomas comparable to the gadolinium-enhanced standard practice? Findings The proposed gadolinium-free diagnosis prediction decision tree for adult-type diffuse gliomas performed well, and gadolinium-enhanced MRI demonstrated only limited improvement in diagnostic accuracy. Clinical relevance Even inexperienced raters effectively classified adult-type diffuse gliomas using the gadolinium-free diagnosis prediction decision tree, which, until further validation, can be used alongside gadolinium-enhanced images to respect standard practice, despite this study showing that gadolinium-enhanced images hardly improved diagnostic accuracy.
Authors
- Vera C. Keil (ORCID: https://orcid.org/0000-0001-8699-3506)
- Yeva Prysiazhniuk (ORCID: https://orcid.org/0000-0001-7384-1693)
- Ivar J. H. G. Wamelink (ORCID: https://orcid.org/0000-0002-4658-1395)
- Aynur Azizova (ORCID: https://orcid.org/0000-0002-9354-2612)
- Pieter Wesseling (ORCID: https://orcid.org/0000-0001-5453-5201)
- Niels Verburg (ORCID: https://orcid.org/0000-0003-1048-1664)
- Elif Kaya (ORCID: https://orcid.org/0000-0001-6388-9714)
- Frederik Barkhof (ORCID: https://orcid.org/0000-0003-3543-3706)
- Jan Petr (ORCID: https://orcid.org/0000-0002-3201-6002)
- Philip C. De Witt Hamer (ORCID: https://orcid.org/0000-0003-2988-8544)
- Marcus Cakmak
Institutions
- Charles University (CZ)
- Dutch Cancer Society (NL)
- Helmholtz-Zentrum Dresden-Rossendorf (DE)
- University Hospital in Motol (CZ)
- Amsterdam Neuroscience (NL)
- Princess Máxima Center (NL)
- Ankara Yıldırım Beyazıt University (TR)
- National Hospital for Neurology and Neurosurgery (GB)
- Amsterdam University Medical Centers (NL)
- Cancer Center Amsterdam (NL)
- University College London (GB)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- European Radiology
- Published
- 2024-10-19
- DOI
- https://doi.org/10.1007/s00330-024-11140-5
- Citations
- 7
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.07
Funders
- National Institute for Health and Care Research
- University College London Hospitals NHS Foundation Trust
- Hanarth Fonds