Role of cuproptosis in mediating the severity of experimental malaria-associated acute lung injury/acute respiratory distress syndrome
Our data demonstrate that the activation of cuproptosis with DSF aggravated the severity of MA-ALI/ARDS by partially inducing M1 polarization of pulmonary macrophages, while inhibition of cuproptosis with TTM contrarily ameliorated the severity of MA-ALI/ARDS by promoting macrophage M2 polarization. Our findings suggest that blockage of cuproptosis could be a potential therapeutic strategy for treatment of MA-ALI/ARDS.
Authors
- Xinpeng Hou
- Bo Huang (ORCID: https://orcid.org/0000-0001-6196-5373)
- Xiaobao Jin (ORCID: https://orcid.org/0000-0001-5450-1730)
- Tingting Zhou (ORCID: https://orcid.org/0000-0001-8084-178X)
- Pinru Chen
- Lirong Wu
- Zhenlong Liu (ORCID: https://orcid.org/0000-0001-9149-7179)
- Qi Wang (ORCID: https://orcid.org/0000-0001-7626-676X)
- Hua Li (ORCID: https://orcid.org/0000-0001-8481-0235)
- Wenbin Liu (ORCID: https://orcid.org/0000-0001-9091-3177)
- Min Zhang (ORCID: https://orcid.org/0000-0002-1345-0604)
Institutions
- Guangdong Pharmaceutical University (CN)
- Hegang People's Hospital (CN)
- Shenzhen Bao'an District People's Hospital (CN)
- Guangzhou Chest Hospital (CN)
- McGill University (CA)
Publication Details
- Journal
- Parasites & Vectors
- Published
- 2024-10-19
- DOI
- https://doi.org/10.1186/s13071-024-06520-1
- Citations
- 4
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 2.17
Funders
- Traditional Chinese Medicine Bureau of Guangdong Province