Proteomic profiling of neutrophils and plasma in community-acquired pneumonia reveals crucial proteins in diverse biological pathways linked to clinical outcome
Our study presents new perspectives on the neutrophil proteome associated with CAP, laying the groundwork for forthcoming patient-centred investigations. Our results could pave the way for targeted strategies to fine-tune neutrophil responses, potentially improving CAP outcomes.
Authors
- Arie J. Hoogendijk (ORCID: https://orcid.org/0000-0002-3082-2289)
- W. Joost Wiersinga (ORCID: https://orcid.org/0000-0003-2277-1343)
- Daniel Faber
- Erik H.A. Michels (ORCID: https://orcid.org/0000-0001-8145-2444)
- Maartje van den Biggelaar (ORCID: https://orcid.org/0000-0001-6970-5496)
- Justin de Brabander (ORCID: https://orcid.org/0000-0002-3596-5086)
- Alex F. de Vos (ORCID: https://orcid.org/0000-0002-2472-3014)
- Osoul Chouchane (ORCID: https://orcid.org/0000-0003-1629-8588)
- Eva R. Smit (ORCID: https://orcid.org/0009-0008-2001-1205)
- Renée A. Douma
- Tom van der Poll
Institutions
- Sanquin (NL)
- Amsterdam University Medical Centers (NL)
- Rijnstate Hospital (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-10-18
- DOI
- https://doi.org/10.3389/fimmu.2024.1470383
- Citations
- 3
- Primary Topic
- Pneumonia and Respiratory Infections
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Landsteiner Foundation for Blood Transfusion Research
- Amsterdam University Medical Centers
- European Commission
- ZonMw
- Horizon 2020