Continuous Flow Synthesis of Five‐Membered N‐Heterocycles by Ynone System
Abstract In this study, we devised a practical and effective method for synthesizing ynones from terminal alkynes and anhydride utilizing a continuous flow apparatus at ambient temperature. Moreover, we coupled the ynones with hydrazines, and hydroxylamine hydrochloride to synthesize pyrazole and isoxazole derivatives. This protocol's unique characteristics include a metal‐free approach, mild reaction conditions, a short residence time, and a wide range of functional group tolerance. Sustainable strategies are most useful and affordable than conventional benchtop approaches.
Authors
- Balaji Ganesan (ORCID: https://orcid.org/0000-0002-1000-254X)
- Yu‐Ting Chiou
- Wei‐Yu Lin (ORCID: https://orcid.org/0000-0003-2631-9581)
- Karthick Govindan (ORCID: https://orcid.org/0000-0002-4310-303X)
- Vijay Thavasianandam Seenivasan
- Mohanraj Kandasamy (ORCID: https://orcid.org/0000-0002-2073-5827)
- Tamilselvan Duraisamy (ORCID: https://orcid.org/0000-0002-1834-7155)
- Li‐Yu Wang
Institutions
- Kaohsiung Medical University (TW)
- Kaohsiung Medical University Chung-Ho Memorial Hospital (TW)
Publication Details
- Journal
- Asian Journal of Organic Chemistry
- Published
- 2024-10-18
- DOI
- https://doi.org/10.1002/ajoc.202400359
- Citations
- 2
- Primary Topic
- Oxidative Organic Chemistry Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.50