N-acetyl-L-cysteine reduces testis ROS in obese fathers but fails in protecting offspring from acquisition of epigenetic traits at cyp19a1 and IGF11/H19 ICR loci
Although NAC supplementation improved the health status and sperm quality of HFD-fed male mice, it did not prevent the epigenetic transmission of metabolic disorders to their offspring. Different NAC dosages and antioxidants other than NAC might represent alternatives to stop the intergenerational transmission of paternal dysmetabolic traits.
Authors
- Melania Murolo (ORCID: https://orcid.org/0000-0001-7930-9905)
- Veronica Porreca
- Gilda Cobellis (ORCID: https://orcid.org/0000-0001-5884-9208)
- Monica Dentice (ORCID: https://orcid.org/0000-0002-9977-3761)
- Nadia Badolati (ORCID: https://orcid.org/0000-0002-1622-6384)
- Valentina Laurenzi
- Mariano Stornaiuolo (ORCID: https://orcid.org/0000-0003-2200-5083)
- Giorgia Musto
- Roberto Ciampaglia (ORCID: https://orcid.org/0000-0002-8734-4249)
- Francesco Manfrevola (ORCID: https://orcid.org/0000-0003-0459-7644)
- Valentina Vellecco (ORCID: https://orcid.org/0000-0002-5674-9112)
- Mariarosaria Bucci (ORCID: https://orcid.org/0000-0001-5502-4315)
- Serena Sagliocchi (ORCID: https://orcid.org/0000-0003-0796-1392)
- Teresa Chioccarelli (ORCID: https://orcid.org/0000-0002-1720-1496)
- Arianna Pastore (ORCID: https://orcid.org/0000-0002-2436-658X)
Institutions
- University of Campania "Luigi Vanvitelli" (IT)
- Telethon Institute Of Genetics And Medicine (IT)
- University of Naples Federico II (IT)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2024-10-18
- DOI
- https://doi.org/10.3389/fcell.2024.1450580
- Citations
- 3
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 3.33