Comparison of sGC activator and sGC stimulator in 5/6 nephrectomized rats on high-salt-diet
In contrast, BAY 41-8543 had no significant impact on these proteins. sGC activators were more effective than sGC stimulators in reducing renal fibrosis in 5/6 nephrectomized rats on a high salt diet, and this effect was due to modulation of apoptosis-associated proteins beyond the control of blood pressure.
Authors
- Mohamed M. S. Gaballa (ORCID: https://orcid.org/0000-0003-2949-430X)
- Philipp Kalk
- Bernhard K. Krämer (ORCID: https://orcid.org/0000-0002-1718-2918)
- Berthold Hocher (ORCID: https://orcid.org/0000-0001-8143-0579)
- Thomas Klein (ORCID: https://orcid.org/0000-0001-5762-9166)
- Yingquan Xiong
- Xin Chen (ORCID: https://orcid.org/0000-0003-4997-1257)
- Denis Delić (ORCID: https://orcid.org/0000-0001-6798-3134)
- Shufei Zeng
Institutions
- Boehringer Ingelheim (Germany) (DE)
- Central South University (CN)
- Benha University (EG)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Reproductive & Genetic Hospital CITIC-Xiangya (CN)
- Nanfang Hospital (CN)
- Academy of Scientific Research and Technology (EG)
- Institut für Medizinische Diagnostik Berlin-Potsdam (DE)
- University Medical Centre Mannheim (DE)
- Southern Medical University (CN)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-10-18
- DOI
- https://doi.org/10.3389/fphar.2024.1480186
- Citations
- 5
- Primary Topic
- Nitric Oxide and Endothelin Effects
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- Academy of Scientific Research and Technology
- China Scholarship Council