Association of glymphatic system dysfunction with cognitive impairment in temporal lobe epilepsy
These findings reveal the important role of the DTI-ALPS index and CPV in SVF performance in unilateral TLE. Decreased DTI-ALPS index and increased CPV are the independent risk factors for semantic fluency impairment. The DTI-ALPS index may fully mediate the relationship between CP enlargement and SVF performance. These insights provide a radiological foundation for further investigations into the mechanism of the glymphatic system in TLE pathophysiology.
Authors
- Xiaona Xia (ORCID: https://orcid.org/0000-0001-5438-2735)
- Bin Zhang (ORCID: https://orcid.org/0000-0002-9280-8247)
- Feng Shi (ORCID: https://orcid.org/0000-0002-1850-7796)
- Xiangshui Meng
- Xiaotian Ma (ORCID: https://orcid.org/0000-0001-6257-696X)
- Wei Ying (ORCID: https://orcid.org/0009-0008-1864-8717)
- Ling Li
- Jiajia Wang (ORCID: https://orcid.org/0009-0005-2547-9059)
Institutions
- Shandong University (CN)
- United Imaging Healthcare (China) (CN)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2024-10-18
- DOI
- https://doi.org/10.3389/fnagi.2024.1459580
- Citations
- 9
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 2.41
Funders
- Qingdao Key Health Discipline Development Fund