KSCN‐Mediated One‐Pot Thiocyanation Tandem Cyclization of Enaminones: a Facile Access to 2‐amino/imino Thiazolo Fused Chromone and Coumarin Frameworks

Abstract A rapid metal‐free approach describing one‐pot thiocyanation of chromone and coumarin enabling tandem cyclization via potassium thiocyanate as a sulfur surrogate was unveiled. Interestingly, this enaminone‐mediated protocol facilitated straightforward access to medicinally significant 2‐amino/imino thiazolo fused chromone and coumarin frameworks. This methodology provided good atom‐economy, remarkable functional group tolerance, and scalability. Alongside establishing a wide substrate scope, it also provided a feasible scalability up to gram scale.