A transcriptomic analysis of dental pulp stem cell senescence in vitro
Increased in vitro expansion induced cellular senescence in pulp stem cells, which resulted in a reduction in their proliferative capacity and osteogenic-lipogenic differentiation potential. The differential expression of genes such as CFH, WNT16, HSD17B2, IDI1, and COL5A3 may represent a potential mechanism for the induction of cellular senescence in pulp stem cells.
Authors
- Mingchang Hu
- Yu Song (ORCID: https://orcid.org/0000-0002-3405-2242)
- Linlin Xu (ORCID: https://orcid.org/0000-0001-5749-3828)
- Longfei Liu (ORCID: https://orcid.org/0000-0003-0274-4057)
- Xuecheng Xu (ORCID: https://orcid.org/0000-0003-4790-3824)
- Jidong Xu
Institutions
- Qingdao University (CN)
- Affiliated Hospital of Qingdao University (CN)
Publication Details
- Journal
- BioMedical Engineering OnLine
- Published
- 2024-10-18
- DOI
- https://doi.org/10.1186/s12938-024-01298-w
- Citations
- 6
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 2.63
Funders
- Qingdao Key Health Discipline Development Fund