Integrated temporal transcriptional and epigenetic single-cell analysis reveals the intrarenal immune characteristics in an early-stage model of IgA nephropathy during its acute injury
This study presents a comprehensive analysis of the dynamic changes in immune cell profiles in a model of IgAN, identifying key cell types and their roles and interactions. These findings significantly contribute to the understanding of the pathogenesis of IgAN and may provide potential targets for therapeutic intervention.
Authors
- Jian Zhou (ORCID: https://orcid.org/0000-0002-3721-4550)
- Yuzhang Wu (ORCID: https://orcid.org/0000-0002-4049-0214)
- Xu Chen (ORCID: https://orcid.org/0000-0003-4303-8116)
- Yiwei Zhang (ORCID: https://orcid.org/0000-0002-5158-4187)
- Hui Dong (ORCID: https://orcid.org/0009-0005-4222-2183)
- Xiangmei Chen (ORCID: https://orcid.org/0000-0001-8774-6021)
- Jiangnan Zhang (ORCID: https://orcid.org/0000-0002-1253-9754)
- Yi Tian (ORCID: https://orcid.org/0000-0003-0635-0573)
Institutions
- Army Medical University (CN)
- People's Liberation Army No. 150 Hospital (CN)
- Xinqiao Hospital (CN)
- Chinese People's Liberation Army (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-10-18
- DOI
- https://doi.org/10.3389/fimmu.2024.1405748
- Citations
- 4
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 1.36
Funders
- National Natural Science Foundation of China
- Major Research Plan