Life-threating complications of immunotherapy: Stevens-Johnson syndrome and toxic epidermal necrolysis

Stevens–Johnson syndrome (SSD) and toxic epidermal necrolysis (TEN) are life–threatening conditions accompanied by skin lesions, as well as in some cases mucous membranes, manifested by necrosis and detachment of the epidermis. These conditions are considered urgent and require emergency hospitalization. Most often, these conditions develop when taking drugs, but in some cases it is not possible to find out the cause of the disease. In described case, we discovered this condition in a patient, who received immunotherapy with pembrolizumab, a monoclonal antibody to the PD-1 receptor, which generally used in the treatment of cancer patients.