ALKBH5 modulation of ferroptosis in recurrent miscarriage: implications in cytotrophoblast dysfunction
Elevated ALKBH5 alleviated RSL3-induced cytotrophoblast cell death by promoting the expression of FTL in patients with RM. Our results supported the view that ALKBH5 is an important regulator of the ferroptosis-related etiology of RM and suggested that ALKBH5 could be responsible for epigenetic aberrations in RM pathogenesis.
Authors
- Chuanmei Qin (ORCID: https://orcid.org/0000-0001-6093-9261)
- Yi Lin (ORCID: https://orcid.org/0000-0001-8956-5734)
- Xueqing Liu (ORCID: https://orcid.org/0000-0002-3227-7448)
- Xiaowei Wei (ORCID: https://orcid.org/0000-0002-3802-7845)
- Jiayi Wu (ORCID: https://orcid.org/0009-0005-5793-655X)
Institutions
- Shanghai Jiao Tong University (CN)
- International Peace Maternity & Child Health Hospital (CN)
Publication Details
- Journal
- PeerJ
- Published
- 2024-10-18
- DOI
- https://doi.org/10.7717/peerj.18227
- Citations
- 5
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- National Natural Science Foundation of China
- Shanghai Jiao Tong University