Shear-Sensing by C-Reactive Protein: Linking Aortic Stenosis and Inflammation
We identify a novel mechanism of shear-induced pCRP dissociation, which results in the activation of cells central to the development of AS. This novel mechanosensing mechanism of pCRP dissociation to mCRP is likely also relevant to other pathologies involving increased shear rates, such as in atherosclerotic and injured arteries.
Authors
- Anna M.D. Watson (ORCID: https://orcid.org/0000-0001-5306-409X)
- Michael W. Parker (ORCID: https://orcid.org/0000-0002-3101-1138)
- Xiaowei Wang (ORCID: https://orcid.org/0000-0001-8658-7399)
- N. Dayawansa (ORCID: https://orcid.org/0000-0002-1863-092X)
- Craig J. Morton (ORCID: https://orcid.org/0000-0001-5452-5193)
- John D. Horowitz (ORCID: https://orcid.org/0000-0001-6883-0703)
- Geoffrey A. Pietersz (ORCID: https://orcid.org/0000-0002-1999-6835)
- Khashayar Khoshmanesh (ORCID: https://orcid.org/0000-0001-6036-7371)
- David Braig (ORCID: https://orcid.org/0000-0002-1267-0840)
- Julia Thomé (ORCID: https://orcid.org/0000-0002-1962-9525)
- Karen S. Cheung Tung Shing (ORCID: https://orcid.org/0000-0002-3817-0860)
- Tracy L. Nero (ORCID: https://orcid.org/0000-0002-3393-1843)
- Antony Walton (ORCID: https://orcid.org/0000-0002-9173-5904)
- Dion Stub (ORCID: https://orcid.org/0000-0001-8686-2709)
- Sara Baratchi (ORCID: https://orcid.org/0000-0003-3588-7951)
- Karlheinz Peter (ORCID: https://orcid.org/0000-0002-8040-2258)
- Prerna Sharma (ORCID: https://orcid.org/0009-0007-6878-7240)
- Mitchell J. Moon (ORCID: https://orcid.org/0000-0001-9345-5001)
- Mark Louis P. Vidallon (ORCID: https://orcid.org/0000-0002-0026-3906)
- Steffen U. Eisenhardt (ORCID: https://orcid.org/0000-0003-4471-3160)
- Angela Huang (ORCID: https://orcid.org/0009-0004-7054-4342)
- Julia Loseff-Silver (ORCID: https://orcid.org/0000-0002-1570-556X)
- Dalton J. E. Harvie (ORCID: https://orcid.org/0000-0002-8501-1344)
- Yung‐Chih Chen (ORCID: https://orcid.org/0000-0002-5387-5818)
- Austin Lai (ORCID: https://orcid.org/0009-0003-6208-5660)
- Abhishek Roy (ORCID: https://orcid.org/0000-0002-9272-6778)
- James D. McFadyen (ORCID: https://orcid.org/0000-0002-9832-6871)
- Johannes Zeller (ORCID: https://orcid.org/0000-0002-8122-9063)
- Anastasia Barbaro-Wahl (ORCID: https://orcid.org/0009-0001-1058-7824)
- Michael B. Bongiovanni
- Nay Htun
Institutions
- Biotechnology Institute (US)
- Baker Heart and Diabetes Institute (AU)
- University Medical Center Freiburg (DE)
- The Alfred Hospital (AU)
- General Department of Preventive Medicine (VN)
- Queen Elizabeth Hospital (AU)
- Maine Farmland Trust (US)
- CSIRO Manufacturing (AU)
- Monash University (AU)
- St Vincents Institute of Medical Research (AU)
- RMIT University (AU)
Publication Details
- Journal
- Circulation Research
- Published
- 2024-10-18
- DOI
- https://doi.org/10.1161/circresaha.124.324248
- Citations
- 20
- Primary Topic
- Cardiac Valve Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 8.04