Harnessing <i>Lactobacillus reuteri</i> ‐Derived Extracellular Vesicles for Multifaceted Cancer Treatment
Extracellular vesicles (EVs) have emerged as valuable biological materials for treating intractable diseases. Extensive studies are conducted on EVs derived from various cellular sources. In this study, EVs derived from Lactobacillus reuteri (L. reuteri), a probiotic, exhibit remarkable cancer therapeutic efficacy when administered orally is reported. These L. reuteri-derived EVs (REVs) demonstrate stability in the gastrointestinal tract and exert significant anti-tumor effects. Using A549 cells and murine models, we confirmed that REVs mediate their therapeutic effects by modulating apoptotic signaling pathways. Furthermore, the combination of REV with drugs enhances tumor ablation and induces immunogenic cell death. In a mouse model, oral administration of REVs encapsulating indocyanine green followed by photothermal therapy led to complete tumor elimination within 32 days. REVs represent a promising biological therapeutic platform for cancer treatment, either independently or in combination with other therapies, depending on the treatment objectives.
Authors
- Suhyeon Kim (ORCID: https://orcid.org/0000-0001-8375-2491)
- Eun‐Kyung Lim (ORCID: https://orcid.org/0000-0003-2793-3700)
- Jinsol Choi (ORCID: https://orcid.org/0000-0002-7308-9347)
- Eunkyeong Jung (ORCID: https://orcid.org/0000-0002-1164-1028)
- Juyeon Jung (ORCID: https://orcid.org/0000-0002-1969-321X)
- Hye Ran Kim (ORCID: https://orcid.org/0000-0002-0658-3345)
- Kwang-sun Kim (ORCID: https://orcid.org/0000-0003-3703-5461)
- Taejoon Kang (ORCID: https://orcid.org/0000-0002-5387-6458)
- Soyeon Yi
Institutions
- Korea University (KR)
- Sejong University (KR)
- Kyung Hee University (KR)
- Pusan National University (KR)
- Korea Research Institute of Bioscience and Biotechnology (KR)
- Sungkyunkwan University (KR)
- Korea University of Science and Technology (KR)
Publication Details
- Journal
- Small
- Published
- 2024-10-18
- DOI
- https://doi.org/10.1002/smll.202406094
- Citations
- 14
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 3.27
Funders
- Ministry of Trade, Industry and Energy
- Ministry of Environment
- Ministry of Agriculture, Food and Rural Affairs
- Korea Research Institute of Bioscience and Biotechnology
- Ministry of Science and ICT, South Korea
- National Institutes of Health
- Korea Environmental Industry and Technology Institute
- Korea Evaluation Institute of Industrial Technology
- National NanoFab Center