Monkeypox Virus Infection Stimulates a More Robust and Durable Neutralizing Antibody Response Compared to Modified Vaccinia Virus Ankara Vaccination
Monkeypox virus (MPXV) has recently caused a global disease outbreak in humans. Differences in the neutralizing antibody response to vaccination versus MPXV infection remain poorly understood. Here, we examined the neutralization of MPXV and vaccinia virus by sera from a cohort of convalescent and vaccinated individuals at 1 and 8 months postexposure. Convalescent individuals displayed higher neutralizing antibody titers against MPXV than vaccinated and MPXV-naive persons at 1 month postexposure. Neutralizing antibody titers had waned significantly in both groups at 8 months. This study suggests that additional vaccine strategies are needed to elicit a durable humoral response and prevent breakthrough infections.
Authors
- Pablo Guardado‐Calvo (ORCID: https://orcid.org/0000-0001-7292-5270)
- Jacob Berrigan
- Gorka Lasso (ORCID: https://orcid.org/0000-0001-5355-323X)
- Emily Happy Miller (ORCID: https://orcid.org/0000-0002-0640-5653)
- Stephanie R. Monticelli (ORCID: https://orcid.org/0000-0002-5031-2534)
- Christopher N. Selverian (ORCID: https://orcid.org/0000-0002-1047-4336)
- Thomas Batchelor (ORCID: https://orcid.org/0009-0002-2086-794X)
- Leandro Battini
- Megan Demouth (ORCID: https://orcid.org/0000-0001-8861-4207)
- Eric A. Meyerowitz (ORCID: https://orcid.org/0000-0001-7954-6548)
- Annalisa Meola (ORCID: https://orcid.org/0000-0003-2582-4463)
- Kartik Chandran (ORCID: https://orcid.org/0000-0003-0232-7077)
- Andrew S. Herbert (ORCID: https://orcid.org/0009-0001-5256-7733)
- Yakin Jaleta (ORCID: https://orcid.org/0009-0008-5484-2760)
Institutions
- Oak Ridge Associated Universities (US)
- Albert Einstein College of Medicine (US)
- Montefiore Medical Center (US)
- Institut Pasteur (FR)
- Université Paris Cité (FR)
- United States Army Medical Research Institute of Infectious Diseases (US)
- The Geneva Foundation (US)
- Oak Ridge Institute for Science and Education
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2024-10-18
- DOI
- https://doi.org/10.1093/infdis/jiae515
- Citations
- 13
- Primary Topic
- Poxvirus research and outbreaks
- Type
- article
- Field-Weighted Citation Impact
- 3.82