Clemastine Induces Oligodendrocyte Progenitor Pool Exhaustion and Senescence in the Context of Chronic Demyelination in a Rabbit Model
Although capable of driving OL differentiation, clemastine treatment in rabbits hampered progenitor pool replenishment, induced senescence, and promoted conversion of microglia/macrophages to a proinflammatory phenotype. Whether these effects would also occur in humans or with other prodifferentiative therapies should be studied further, but our data suggest the need to carefully consider progenitor dynamics in the treatment of MS. ANN NEUROL 2024.
Authors
- Rupadevi Muthaiah
- Fraser J. Sim (ORCID: https://orcid.org/0000-0002-3942-6637)
- James J. M. Cooper (ORCID: https://orcid.org/0000-0002-4760-2784)
- Gemma Buck (ORCID: https://orcid.org/0000-0001-5289-1050)
- Faye D. Raymond
- Roopa Ravichandar
- Farah Gadelkarim (ORCID: https://orcid.org/0000-0002-8196-9053)
- J. C. Frost
Institutions
- University at Buffalo, State University of New York (US)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2024-10-18
- DOI
- https://doi.org/10.1002/ana.27098
- Citations
- 7
- Primary Topic
- Neurogenesis and neuroplasticity mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 2.88
Funders
- National Multiple Sclerosis Society
- National Institute of Neurological Disorders and Stroke
- Congressionally Directed Medical Research Programs