Effect and mechanism of allergen‐specific immunotherapy on small airway dysfunction in children with asthma
Our study demonstrated that HDM AIT not only improved SAD related lung function parameters, but also reduced basophil activity. RNA sequencing revealed the inhibition of phagocytosis and the phagosome pathway in basophils which may affect the polarization of Th2 cell differentiation after HDM AIT.
Authors
- Wenfang Dong (ORCID: https://orcid.org/0000-0002-5873-2517)
- Wenwei Zhong (ORCID: https://orcid.org/0000-0003-1629-224X)
- Lin Yang (ORCID: https://orcid.org/0000-0002-4028-9801)
- Xiaolan Ying
- H. Li (ORCID: https://orcid.org/0000-0001-8785-7792)
- Lei Zhang (ORCID: https://orcid.org/0000-0001-5534-3789)
- Jie Lin (ORCID: https://orcid.org/0000-0003-3535-5250)
- Jinhong Wu (ORCID: https://orcid.org/0000-0002-6113-5908)
- Yong Yin (ORCID: https://orcid.org/0000-0001-9718-6988)
Institutions
- Shanghai Jiao Tong University (CN)
- XinHua Hospital (CN)
- Shanghai Children's Medical Center (CN)
Publication Details
- Journal
- Pediatric Pulmonology
- Published
- 2024-10-18
- DOI
- https://doi.org/10.1002/ppul.27341
- Primary Topic
- Allergic Rhinitis and Sensitization
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China