HLA DQA1*05 and Risk of Antitumor Necrosis Factor Treatment Failure and Anti-Drug Antibody Development in Children With Crohn's Disease
In a randomized trial of children with CD initiating anti-TNF, 40% were HLA DQ-A1*05 positive, which was associated with a trend toward increased risk of both treatment failure and ADA. These risks were mitigated, but not eliminated, by adding oral methotrexate. HLA DQ-A1*05 is an important biomarker for prognosis and risk stratification.
Authors
- Rana Ammoury (ORCID: https://orcid.org/0009-0003-9645-0451)
- Traci Jester
- Jillian S. Sullivan (ORCID: https://orcid.org/0009-0000-7521-1345)
- Michael D. Kappelman (ORCID: https://orcid.org/0000-0002-0469-6856)
- Ann M. Firestine (ORCID: https://orcid.org/0000-0001-9734-9687)
- Charles M. Samson (ORCID: https://orcid.org/0000-0003-3701-7327)
- Jennifer Strople (ORCID: https://orcid.org/0000-0001-5357-9755)
- Zarela Molle‐Rios (ORCID: https://orcid.org/0000-0001-6495-0812)
- Steven J. Steiner (ORCID: https://orcid.org/0000-0002-7461-3905)
- Jonathan Moses (ORCID: https://orcid.org/0000-0002-6660-4494)
- Kelly Sandberg (ORCID: https://orcid.org/0000-0001-8927-0434)
- Dinesh S. Pashankar (ORCID: https://orcid.org/0000-0003-0815-8809)
- Jess L. Kaplan (ORCID: https://orcid.org/0000-0003-2022-0767)
- Prateek Wali (ORCID: https://orcid.org/0000-0001-5638-1226)
- Ian Leibowitz
- Kelly Olano
- Ajay Gulati (ORCID: https://orcid.org/0000-0002-7612-6369)
- Tiffany M. Linville (ORCID: https://orcid.org/0009-0001-3929-2413)
- Peter A. Margolis (ORCID: https://orcid.org/0000-0002-2585-4630)
- Shehzad A. Saeed (ORCID: https://orcid.org/0000-0002-5534-7891)
- Phillip Minar (ORCID: https://orcid.org/0000-0003-4223-4211)
- Athos Bousvaros
- Dawn R. Ebach (ORCID: https://orcid.org/0000-0001-5399-1387)
- Jill Dorsey (ORCID: https://orcid.org/0009-0008-7329-3007)
- Joseph A. Galanko (ORCID: https://orcid.org/0000-0003-2304-4375)
- Hans Herfarth (ORCID: https://orcid.org/0000-0003-4268-823X)
- Brendan Boyle (ORCID: https://orcid.org/0000-0002-6679-1584)
- Keith Benkov (ORCID: https://orcid.org/0000-0003-3232-7705)
- Lisa Pitch (ORCID: https://orcid.org/0000-0002-6937-5754)
- Kelly Chun (ORCID: https://orcid.org/0000-0001-5063-2805)
- Jeremy Adler (ORCID: https://orcid.org/0000-0002-4857-6098)
- José Cabrera
Institutions
- University of Vermont (US)
- University of North Carolina at Chapel Hill (US)
- University of Iowa (US)
- Cincinnati Children's Hospital Medical Center (US)
- Boston Children's Hospital (US)
- Lurie Children's Hospital (US)
- Nationwide Children's Hospital (US)
- Children's National (US)
- Harvard University (US)
- George Washington University (US)
- Wright State University (US)
- SUNY Upstate Medical University (US)
- Medical College of Wisconsin (US)
- Washington University in St. Louis (US)
- University of Michigan (US)
- LabCorp (United States) (US)
- Riley Hospital for Children (US)
- Children's of Alabama (US)
- University of Alabama at Birmingham (US)
- Yale University (US)
- Massachusetts General Hospital (US)
- Nemours Children's Health System (US)
- Michigan Medicine (US)
- Dayton Children's Hospital (US)
- Levine Children's Hospital (US)
- Children's Hospital of The King's Daughters (US)
- Rainbow Babies & Children's Hospital (US)
- C. S. Mott Children's Hospital (US)
- Nemours Children's Clinic (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- University of Cincinnati (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- The American Journal of Gastroenterology
- Published
- 2024-10-18
- DOI
- https://doi.org/10.14309/ajg.0000000000003135
- Citations
- 5
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 2.75
Funders
- Patient-Centered Outcomes Research Institute
- Leona M. and Harry B. Helmsley Charitable Trust